The left channel of my 2i2 has very poor common mode rejection:

The left channel CMRR measures 13.5 dB; the right channel is almost 48 dB.
With the input cables shorted the difference in hum signature is pretty large:

The input controls are at the 10 o'clock position which is unity gain.
The poor common mode rejection of the 2i2's Left input makes a THAT1646 balanced output appear noisier than it is.
Both channels are connected to the same 1646 output:

The left channel measures about 13 dB higher because the common mode noise in the 1646 output is being converted to a differential signal by the 2i2's "bad" input. (FWIW a DRV134 or SSM2142 would show similar characteristics due to all three parts having high CM gain.)
The right channel is near the noise floor of the 2i2 - the 1646 noise is a few dB lower.
When the 1646 OutSmarts circuitry is defeated the common mode output noise drops and the noise measurements are close to one another:

I don't know if I have defective 2i2 or not.
It seems hard to believe that component tolerance could be bad enough to make CMRR that low.
I've got a second 2i2 on order and am anxious to test it.
I would recommend everyone check the CMRR of their 2i2 inputs because it introduces measurement errors with active balanced outputs and has greatly reduced hum rejection.